A large-scale study of 20,880 participants revealed a link between higher daytime body temperature and more severe depressive symptoms, with sensor data indicating that for each unit increase in depression severity, body temperature rose by 0.06°C.
The Study at a Glance
• Conducted over seven months, this research analyzed data from the TemPredict Study, including 112,649 days of wearable sensor data and self-reported health assessments.
• Participants provided 51,717 self-reported depression scores using the PHQ-8 scale, a standard measure of depression severity.
• Each 1°C increase in self-reported body temperature correlated with a 0.29-unit increase in depression severity on the PHQ-8 scale.
• Sensor-measured body temperature followed a similar trend, with each 0.1°C rise linked to a 0.06-unit increase in depressive symptoms.
How Temperature and Depression Connect
• People with higher daytime body temperatures showed more severe depressive symptoms, suggesting a link between thermal regulation and mood disorders.
• The difference between awake and asleep body temperature, known as diurnal temperature variation, was lower in individuals with higher depression scores.
• These findings hint at circadian rhythm disruptions, a factor already associated with mood disorders.
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Future Implications
With depression affecting over 280 million people worldwide, understanding biological factors like body temperature regulation could open new treatment possibilities. If further studies confirm these findings, temperature-based interventions, such as controlled heat exposure or medications targeting thermoregulation, may revolutionize depression treatment.
