CARDIO CARE

1. Effect of Terminalia Arjuna on Total Platelet Count and Lipid Profile in Patients of Coronary Artery Disease (2019, Advances in Human Biology)
2. Polyphenolic Profile and Biological Activity of Chinese Hawthorn (Crataegus pinnatifida BUNGE) Fruits (2012, Molecules)
3. The effect of ginger supplementation on lipid profile: A systematic review and meta-analysis of clinical trials (2018. Phytomedicine, National Center for Biotechnology Information)
4. Effects of Capsicum annuum supplementation on the lipid profile in adults with metabolic syndrome: a systematic review and meta-analysis of RCTs (2023, A. Hjazi et al.) – Capsicum supplementation significantly reduced total cholesterol (TC) by ~4.98 mg/dL.  
5. Lipid-Lowering Efficacy of the Capsaicin in Patients With Metabolic Syndrome (2022, Z. Jiang et al.) – Capsaicin supplementation lowered TC and LDL-C in patients with metabolic syndrome.  
6. Red pepper attenuates cholesteryl ester transfer protein and atherosclerosis (2003, M.J. Kwon et al.) – Red pepper reduced CETP activity (a marker linked with cholesterol transport) and slowed atherosclerosis in cholesterol-fed models.  
7. Terminalia arjuna bark extract impedes foam cell formation and promotes macrophage/foam-cell apoptosis(2019, S. Bhansali et al.) – Arjuna extract inhibited foam cell formation by downregulating CD36 expression and promoted apoptosis in macrophages/foam cells.  
8. Hawthorn extract alleviates atherosclerosis through regulating inflammation and apoptosis related factors(2019, S.Z. Wang et al.) – Hawthorn extract reduced inflammatory markers (MCP-1, IL-1β, hs-CRP) and modulated Bax/Bcl-2 expression to stabilize plaques.  
9. Hawthorn leaf flavonoids attenuate atherosclerosis in ApoE-knockout mice by promotion of reverse cholesterol transport and foam cell inhibition (2020, A. Nazhand et al.) – Hawthorn flavonoids improved reverse cholesterol transport, inhibited foam cell formation, and reduced vascular lipid accumulation.  
10. Exploring the mechanism of hawthorn leaves against coronary heart disease via network pharmacology and in vitro validation (2022, J. Ding et al.) – Hawthorn polyphenols suppressed MMP2, MMP9, IL-6, IL-1β and macrophage activation, consistent with plaque-stabilizing, anti-inflammatory effects.  
11. The effects of Capsinoids and Fermented Red Pepper Products on lipid profiles: meta-analysis of RCTs(2022, M.R. Amini et al.) – Capsinoids (from red pepper) significantly reduced total cholesterol (TC) with mild effect on LDL, HDL, or TG.  
12. A Randomized Controlled Clinical Study to Evaluate the Effect of Terminalia Arjuna (Add-On Medication) on Cardiac Function in Coronary Artery Disease (2024, International Research Journal of Multidisciplinary Scope)
13. Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: A randomized, double-blind, placebo-controlled trial (2011, School of Medicine, University of Valencia, Valencia, Spain)
14. Ginger Extract Consumption Reduces Plasma Cholesterol, Inhibits LDL Oxidation and Attenuates Development of Atherosclerosis in Atherosclerotic, Apolipoprotein E-Deficient Mice (2023, The Rappaport Family Institute for Research in the Medical Sciences)
15. Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha) (2022, AHA|ASA Journals)

DOSAGE: Adults should take 1 capsule in the morning, 1 capsule in the afternoon, and 1 capsule before bedtime.

ROUTINE: Consume daily, following this three-times-a-day regimen.

CYCLE: After three weeks of consistent use, take a one-week break. After this break, you may resume the regimen with Cardio Care.