NERVE AID

1. Valerian for Sleep: A Systematic Review and Meta-Analysis (2006, UCSF; Am J Med) – Valerian was associated with improved subjective sleep quality in adults with insomnia.  
2. Valerian-Hops Combination and Diphenhydramine for Treating Insomnia: A Randomized Placebo-Controlled Clinical Trial (2005, Université Laval; Sleep) – Valerian+hops produced a modest hypnotic effect and better quality of life vs placebo.  
3. Clinical Efficacy of a Fixed Valerian-Hops Extract Combination (Ze 91019) (2007, University of Bonn/Max Zeller; Phytother Res) – Reduced sleep latency and improved sleep in non-organic sleep disorder.  
4. Sleep-Improving Effects of a Single Dose Valerian/Hops Fluid Extract: Double-Blind Sleep-EEG Study (2008, Justus Liebig University; Eur J Med Res) – Single dose valerian+hops increased EEG-derived sleep quantity vs placebo.  
5. Effects of a Valerian-Hops Extract (Ze 91019) on Sleep Duration: Randomized, Double-Blind Trial (2025, University of Würzburg; Brain & Behavior) – Increased sleep duration without daytime cognitive downsides.  
6. Herbal and Natural Supplements for Improving Sleep (Review) (2024, Kyung Hee University; Nutrients) – Hopscomponents support sleep via GABA/serotonin/melatonin pathways, with clinical evidence of sleep improvement.  
7. American Skullcap (Scutellaria lateriflora): Randomised, Double-Blind, Placebo-Controlled Crossover Study(2014, University of Westminster; Phytother Res) – Skullcap improved global mood/reduced anxiety, supporting better sleep.  
8. Chemically Characterized Scutellaria lateriflora Extract for Sleep Management: Randomized, Double-Blind Crossover Trial (2025, University of Naples Federico II; Nutrients) – Skullcap significantly improved PSQI, sleep efficiency, and total sleep time vs placebo.  
9. Efficacy and Tolerability of Black Cohosh (Actaea racemosa) Extracts in Menopausal Women (2006, University of Göttingen; Maturitas) – Improved sleep quality alongside other vasomotor symptoms.  
10. Capsaicin 8% Patch in Painful Diabetic Peripheral Neuropathy (2017, Mount Sinai; Pain Med) – Topical capsaicin improved sleep quality secondary to pain reduction.  

For sleep support, adults may take 2–3 capsules approximately 1 hour before bedtime.

For comprehensive nervous system and mental wellness support, take 2 capsules in the morning, 2 in the afternoon, and 2 before bed.